Her work has been collected by the Museum of Fine Arts, Boston; Mexic-Arte Museum, Austin; San Antonio Museum of Art; McNay Art Museum, Meadows Museum, Dallas; and the Art Museum of South Texas, Corpus Christi. Huerta has attended residencies at the McColl Center for the Arts in Charlotte, North Carolina, Coronado Studio in Austin, Texas, and Self Help Graphics in Los Angeles, California.
Huerta has worked on numerous public art projects, most of them involving the community, design teams and fabricators. Projects completed include transit stations in Dallas for the Dallas Area Transit System, the Charlotte Area Transit System and the Phoenix Metro. In addition to transit projects, Huerta has completed streetscape and park projects. Her studio work is in mixed media combining text and images that allude to personal reflection as well as universal themes about identity, love, death, pain and joy. She is a native San Antonian, her family dates back several generations in San Antonio and Brownsville. Huerta maintains a studio and home outside of San Antonio.
Leticia Huerta has created integral artwork for each of the three bridges in the Lower Lebow Channel Watershed Improvement Project; Northeast 28th Street at Decatur, Dewey Street at Decatur and now Brennan Avenue at Guenther Avenue. Across all three bridges, her imagery draws upon the history of the Fort Worth stockyards, meat packing plants and the multicultural history of the people that settled the area.